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Nat Med. 2017 Jun;23(6):678-680. doi: 10.1038/nm.4330. Epub 2017 May 1.

Silent hippocampal seizures and spikes identified by foramen ovale electrodes in Alzheimer's disease.

Author information

1
MGH Epilepsy Service, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
2
Department of Neurology, Baylor College of Medicine, Houston, Texas, USA.
3
Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.

Abstract

We directly assessed mesial temporal activity using intracranial foramen ovale electrodes in two patients with Alzheimer's disease (AD) without a history or EEG evidence of seizures. We detected clinically silent hippocampal seizures and epileptiform spikes during sleep, a period when these abnormalities were most likely to interfere with memory consolidation. The findings in these index cases support a model in which early development of occult hippocampal hyperexcitability may contribute to the pathogenesis of AD.

PMID:
28459436
PMCID:
PMC5461182
DOI:
10.1038/nm.4330
[Indexed for MEDLINE]
Free PMC Article

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