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Carbohydr Res. 2017 Jun 5;445:75-79. doi: 10.1016/j.carres.2017.04.014. Epub 2017 Apr 15.

Flavanonol glucosides from the aerial parts of Agrimonia pilosa Ledeb. and their acetylcholinesterase inhibitory effects.

Author information

1
College of Pharmacy, Catholic University of Daegu, Gyeongsan 38430, Republic of Korea.
2
College of Pharmacy, Catholic University of Daegu, Gyeongsan 38430, Republic of Korea; Phutho College of Pharmacy, Viettri City, Phutho Province 290000, Viet Nam.
3
College of Pharmacy, Catholic University of Daegu, Gyeongsan 38430, Republic of Korea. Electronic address: woomh@cu.ac.kr.

Abstract

Two new flavanonol glucoside isomers, (2R,3S)-dihydrokaempferol 3-O-β-D-glucoside (1) and (2S,3R)-dihydrokaempferol 3-O-β-D-glucoside (2), were isolated from the aerial parts of Agrimonia pilosa Ledeb., along with eight known flavanonol glucosides (3-10). Their structures were determined on the basis of spectroscopic analysis. In addition, these compounds were evaluated to determine their acetylcholinesterase inhibitory activities. The results indicated that these compounds have moderate inhibitory effects, with IC50 values ranging from 76.59 ± 1.16 to 97.53 ± 1.64 μM, except compounds 1 and 4 were inactive.

KEYWORDS:

Acetylcholinesterase activity; Agrimonia pilosa; Flavanonol glucoside

PMID:
28458099
DOI:
10.1016/j.carres.2017.04.014
[Indexed for MEDLINE]

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