Format

Send to

Choose Destination
Tissue Eng Part A. 2017 Oct;23(19-20):1152-1159. doi: 10.1089/ten.TEA.2016.0538. Epub 2017 May 19.

Extracellular Matrix Bioscaffolds as Immunomodulatory Biomaterials<sup/>.

Author information

1
1 McGowan Institute for Regenerative Medicine, University of Pittsburgh , Pittsburgh, Pennsylvania.
2
2 Department of Bioengineering, University of Pittsburgh , Pittsburgh, Pennsylvania.
3
3 Department of Surgery, University of Pittsburgh School of Medicine , Pittsburgh, Pennsylvania.

Abstract

Suppression of the recipient immune response is a common component of tissue and organ transplantation strategies and has also been used as a method of mitigating the inflammatory and scar tissue response to many biomaterials. It is now recognized, however, that long-term functional tissue replacement not only benefits from an intact host immune response but also depends upon such a response. The present article reviews the limitations associated with the traditionally held view of avoiding the immune response, the ability of acellular biologic scaffold materials to modulate the host immune response and promote a functional tissue replacement outcome, and current strategies within the fields of tissue engineering and biomaterials to develop immune-responsive and immunoregulatory biomaterials.

KEYWORDS:

ECM bioscaffolds; host response; macrophage

PMID:
28457179
PMCID:
PMC6112165
DOI:
10.1089/ten.TEA.2016.0538
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Atypon Icon for PubMed Central
Loading ...
Support Center