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Arch Physiol Biochem. 2017 Oct;123(4):265-278. doi: 10.1080/13813455.2017.1317815. Epub 2017 May 1.

Molecular effects of hesperetin, a citrus flavanone on7,12-dimethylbenz(a)anthracene induced buccal pouch squamous cell carcinoma in golden Syrian hamsters.

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a Department of Biochemistry and Biotechnology, Faculty of Science , Annamalai University , Annamalainagar , Tamilnadu , India.
b Department of Oral and Maxillofacial Pathology, Faculty of Dentistry, Rajah Muthiah Dental College and Hospital , Annamalai University , Annamalainagar , Tamilnadu , India.


In recent years, researchers have been focused on citrus flavanone, a naturally occurring bioactive substance of hesperetin. To investigate the molecular mechanism based chemopreventive efficacy of hesperetin on 7,12-dimethylbenz(a)anthracene (DMBA) induced hamster buccal pouch (HBP) squamous cell carcinoma (SCC). The oral tumour was provoked by painted with 0.5% DMBA on left buccal pouch thrice a week for 10 consecutive weeks developed well-differentiated SCC and tumour formation was 100% in DMBA alone. We evaluated the chemopreventive potential of hesperetin by assessing the lipid peroxidation (LPO) by-products, status of enzymatic, non-enzymatic antioxidants, detoxifying agents etc. Moreover, modulating expression of apoptotic and cell proliferation markers were observed in HBP SCC experimental hamsters. Oral administration of hesperetin (20 mg/kg b.w.) to DMBA painted hamsters significantly reversed the stages of oral SCC. Our findings indicate that hesperetin possesses a chemopreventive effect in DMBA-induced oral SCC by exerting anti-carcinogenic property.


Hesperetin; antioxidants; apoptosis; detoxification agents

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