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Int Arch Allergy Immunol. 2017;172(4):203-214. doi: 10.1159/000464325. Epub 2017 Apr 29.

Allergens of Blomia tropicalis: An Overview of Recombinant Molecules.

Author information

1
Laboratório de Alergia e Acarologia, Instituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador, Brazil.

Abstract

Allergic diseases are considered a major problem for healthcare systems in both developed and developing countries. House dust mites are well-known triggers of allergic manifestations. While the Dermatophagoides genus is widely distributed globally, Blomia tropicalis is the most prominent mite species in the tropical and subtropical regions of the world. Over the last decades, an increase in sensitization rates to B. tropicalis has been reported, leading to increased research efforts on Blomia allergens. In fact, 8 new allergens have been identified and characterized to different degrees. Here, we provide an overview of recent developments concerning the identification and production of recombinant Blomia allergens, as well as their structural and immunological characterization. Although considerable progress has been achieved, detailed molecule-based studies are still needed to better define the clinical relevance of Blomia allergens. Thus, the establishment of a well-standardized and fully characterized panel of allergens remains a challenge for the development of better diagnosis and therapy of allergic diseases induced by B. tropicalis.

KEYWORDS:

Blomia tropicalis; Cross-reactivity; Immunoglobulin E epitopes; Recombinant allergens; Secondary structure; T-cell epitopes; Three-dimensional structure

PMID:
28456805
PMCID:
PMC5472214
DOI:
10.1159/000464325
[Indexed for MEDLINE]
Free PMC Article

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