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J Theor Biol. 2017 Jun 21;423:53-62. doi: 10.1016/j.jtbi.2017.04.025. Epub 2017 Apr 27.

Analysis of stability to cheaters in models of antibiotic degrading microbial communities.

Author information

1
MTA-ELTE, Theoretical Biology and Evolutionary Ecology Research Group Department of Plant Systematics, Ecology and Theoretical Biology, Pázmány Péter sétány 1/c, Budapest, 1117, Hungary; MTA Centre for Ecological Research, Evolutionary Systems Research Group, Klebelsberg K. u. 3, Tihany, 8237, Hungary; Conflict and Cooperation in Evolutionary Systems Program, Institute of Advanced Studies Kőszeg, Chernel utca 14, Kőszeg, 9730, Hungary.
2
Department of Plant Systematics, Ecology and Theoretical Biology, Eötvös University, Pázmány Péter sétány 1/c, Budapest, 1117, Hungary; International Institute for Applied Systems Analysis (IIASA), Evolution and Ecology Program and Risk and Resilience Program, Schlossplatz 1, Laxenburg, A-2361, Austria.
3
MTA-ELTE, Theoretical Biology and Evolutionary Ecology Research Group Department of Plant Systematics, Ecology and Theoretical Biology, Pázmány Péter sétány 1/c, Budapest, 1117, Hungary. Electronic address: istvan.scheuring@ttk.elte.hu.

Abstract

Antibiotic resistance carried out by antibiotic degradation has been suggested recently as a new mechanism to maintain coexistence of microbial species competing on a single limiting resource, even in well-mixed homogeneous environments. Species diversity and community stability, however, critically depend on resistance against social cheaters, mutants that do not invest in production, but still enjoy the benefits provided by others. Here we investigate how different mutant cheaters affect the stability of antibiotic producing and degrading microbial communities. We consider two cheater types, production and degradation cheaters. We generalize the mixed inhibition-zone and chemostat models introduced previously [Kelsic, E. D., Zhao, J., Vetsigian, K., Kishony, R., 2015. Counteraction of an tibiotic production and degradation stabilizes microbial communities. Nature521, 516-519.] to study the population dynamics of microbial communities in well-mixed environment, and analyze the invasion of different cheaters in these models. We show that production cheaters, mutants that cease producing antibiotics, always destroy coexistence whenever there is a cost of producing these antibiotics. Degradation cheaters, mutants that loose their function of producing extracellular antibiotic degrading molecules, induce community collapse only if the cost of producing the degradation factors is above a critical level. Our analytical studies, supported by numerical simulations, highlight the sensitivity of antibiotic producing and degrading communities to loss-of-function mutants.

KEYWORDS:

Antibiotic-mediated microbiome; Degradation resistance; Evolutionary instability; Rock-paper-scissors; Social parasite

PMID:
28456462
DOI:
10.1016/j.jtbi.2017.04.025
[Indexed for MEDLINE]

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