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Breast. 2017 Aug;34:12-17. doi: 10.1016/j.breast.2017.04.011. Epub 2017 Apr 26.

Thyroid disorders and mammographic density in Spanish women: Var-DDM study.

Author information

1
Cancer and Environmental Epidemiology Unit, National Center for Epidemiology, Carlos III Institute of Health, Madrid, Spain.
2
Cancer and Environmental Epidemiology Unit, National Center for Epidemiology, Carlos III Institute of Health, Madrid, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública), CIBERESP, Spain; Cancer Epidemiology Research Group, Oncology and Hematology Area, IIS Puerta de Hierro (IDIPHIM), Madrid, Spain.
3
Cancer Prevention and Control Unit, Catalan Institute of Oncology (ICO), Barcelona, Spain.
4
Balearic Islands Breast Cancer Screening Program, Health Promotion for Women and Childhood, General Directorate Public Health and Participation, Regional Authority of Health and Consumer Affairs, Balearic Islands, Palma de Mallorca, Spain.
5
Galicia Breast Cancer Screening Program, Regional Authority of Health, Galicia Regional Government, Corunna, Spain.
6
Castile-Leon Breast Cancer Screening Program, General Directorate Public Health SACYL, Burgos, Castile-Leon, Spain.
7
Aragon Breast Cancer Screening Program, Health Service of Aragon, Zaragoza, Spain.
8
Navarra Breast Cancer Screening Program, Public Health Institute, Pamplona, Spain.
9
Valencia Breast Cancer Screening Program, General Directorate Public Health, Valencia, Spain.
10
Institute of Computer Technology, Universitat Politècnica de València, Valencia, Spain.
11
Cancer and Environmental Epidemiology Unit, National Center for Epidemiology, Carlos III Institute of Health, Madrid, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública), CIBERESP, Spain.
12
Cancer and Environmental Epidemiology Unit, National Center for Epidemiology, Carlos III Institute of Health, Madrid, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública), CIBERESP, Spain; Cancer Epidemiology Research Group, Oncology and Hematology Area, IIS Puerta de Hierro (IDIPHIM), Madrid, Spain. Electronic address: bperez@isciii.es.

Abstract

OBJECTIVES:

The association between breast cancer (BC) and thyroid disorders has been widely explored with unclear results. Mammographic density (MD) is one of the strongest risk factor for BC. This study explores the relationship between thyroid diseases and MD in Spanish women.

MATERIALS & METHODS:

This cross-sectional study covered 2883 women aged 47-71 years participating in 7 BC screening programs in 2010. They allowed access to their mammograms, had anthropometrical-measures taken, and answered a telephonic epidemiological interview which included specific questions on thyroid diseases. Percentage of MD was assessed with a semiautomatic-computer tool (DM-scan) by two trained radiologists. We calculated the geometric mean of MD percentages (mean MD). Multivariable mixed linear regression models with random screening-center-specific intercepts were fitted, using log-transformed percentage of MD as dependent variable and adjusting for age, body mass index, menopausal status and other confounders. eβ represents the relative increase of mean MD.

RESULTS:

13.9% of the participants reported personal history of thyroid disease. MD was not associated to hyperthyroidism (eβ:1.05, 95%CI: 0.82-1.36), hypothyroidism (eβ:1.02, 95%CI: 0.75-1.38), thyroid nodules (eβ:1.01, 95%CI: 0.85-1.19) or thyroid cancer (eβ:1.03, 95%CI: 0.56-1.92). However, women with goiter had lower MD (mean MDno-goiter: 13.4% vs mean MDgoiter: 10.6%; eβ:0.79, 95%CI: 0.64-0.98) and those with Hashimoto thyroiditis had higher MD (mean MDno-thyroiditis: 13.3% vs mean MDthyroidits: 25.8%; eβ:1.94, 95%CI: 1.00-3.77).

CONCLUSION:

Functional thyroid disorders were not related to MD. However, MD was lower in women with goiter and higher in those reporting Hashimoto's thyroiditis. These relationships should be confirmed in future studies.

KEYWORDS:

Goiter; Hashimoto thyroiditis; Hyperthyroidism; Hypothyroidisms; Mammographic density; Thyroid

PMID:
28456099
DOI:
10.1016/j.breast.2017.04.011
[Indexed for MEDLINE]

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