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Chem Biol Interact. 2017 Jun 1;271:15-23. doi: 10.1016/j.cbi.2017.04.021. Epub 2017 Apr 25.

Mangiferin attenuates blast-induced traumatic brain injury via inhibiting NLRP3 inflammasome.

Author information

1
Department of Pharmacy, The People's Hospital of Leshan, Leshan 614000, Sichuan, People's Republic of China.
2
Department of Pharmacy, Chengdu Military General Hospital, No.270, Rongdu Avenue, Jinniu District, Chengdu 610083, Sichuan, People's Republic of China.
3
School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610013, Sichuan, People's Republic of China; Department of Pharmacy, Chengdu Military General Hospital, No.270, Rongdu Avenue, Jinniu District, Chengdu 610083, Sichuan, People's Republic of China.
4
Department of Neurosurgery, Chengdu Military General Hospital, No.270, Rongdu Avenue, Jinniu District, Chengdu 610083, Sichuan, People's Republic of China.
5
School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610013, Sichuan, People's Republic of China; Department of Traditional Chinese Medicine, Chengdu Military General Hospital, No.270, Rongdu Avenue, Jinniu District, Chengdu 610083, Sichuan, People's Republic of China. Electronic address: huyhzyy@163.com.
6
The 306th Hospital of PLA, NO.9, Anxiang Beili, Deshengmen, Chaoyang District, Beijing 100101, People's Republic of China. Electronic address: gujianwen5000@sina.com.
7
Department of Pharmacy, Chengdu Military General Hospital, No.270, Rongdu Avenue, Jinniu District, Chengdu 610083, Sichuan, People's Republic of China. Electronic address: baotao_yu@sina.com.

Abstract

There is growing evidence that Mangiferin possess therapeutic benefit during neuroinflammation on various brain injury models due to its anti-inflammatory properties. It is reported that inflammatory plays a crucial role in the pathogenesis of secondary injury induced by the blast-induced traumatic brain injury (bTBI). However, the role of mangiferin in bTBI is yet to be studied. In our study, the potential effect of mangiferin in the duration of bTBI was examined first. Fortunately, the amelioration of cerebral cortex damage was found in rats suffering bTBI after mangiferin administration. Furthermore, the detail mechanism of mangiferin's beneficial actions in bTBI was also studied. The results revealed that mangiferin might alleviate brain damage in rats with bTBI by inhibiting the NOD-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome activation, which was accompanied by mangiferin's inhibition of oxidative stress and pro-inflammatory cytokines production. Therefore, this research allows us to speculate that, for first time, NLRP3 is involved in the anti-inflammatory effect of mangiferin in the cerebral cortex, and mangiferin could be a potential therapy drug for bTBI.

KEYWORDS:

Blast-induced traumatic brain injury; Inflammation; Mangiferin; NLRP3; Oxidative stress

PMID:
28455230
DOI:
10.1016/j.cbi.2017.04.021
[Indexed for MEDLINE]

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