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Exp Eye Res. 2017 Jul;160:31-37. doi: 10.1016/j.exer.2017.04.008. Epub 2017 Apr 25.

Lutein and its oxidized forms in eye structures throughout prenatal human development.

Author information

1
Koltsov Institute of Developmental Biology, Russian Academy of Sciences, ul. Vavilova 26, Moscow 119334, Russia. Electronic address: pinag@mail.ru.
2
Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, ul. Kosygina 4, Moscow 119334, Russia.
3
Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, ul. Kosygina 4, Moscow 119334, Russia; Research Center of Obstetrics, Gynecology, and Perinatology, Russian Academy of Medical Sciences, ul. Akademika Oparina 4, Moscow 117997, Russia; Moscow Institute of Physics and Technology, Dolgoprudnyi, Moscow Region 141700, Russia.
4
Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, ul. Kosygina 4, Moscow 119334, Russia; Department of Molecular Physiology, Biological Faculty, Lomonosov State University, Leninskie Gory 1, 119991, Russia.
5
Research Center of Obstetrics, Gynecology, and Perinatology, Russian Academy of Medical Sciences, ul. Akademika Oparina 4, Moscow 117997, Russia.
6
Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, ul. Kosygina 4, Moscow 119334, Russia; Moscow Institute of Physics and Technology, Dolgoprudnyi, Moscow Region 141700, Russia.

Abstract

The presence of carotenoids in the vitreous body, retina, lens, retinal pigment epithelium together with choroid (hereinafter RPE), and ciliary body and iris together with choroidal stroma (hereinafter CBI) was studied throughout the second trimester of prenatal development of the human eye. It has been found that the vitreous body, retina, and RPE contain lutein and its oxidized forms. Zeaxanthin was not found in the tissues studied. The presence of lutein in the vitreous body is transient and no longer detected after 28 weeks of gestation. Lutein was not detected in the lens and CBI, but its oxidized forms were found. The presence of carotenoids in different tissues of the eye in the course of normal eye development and the antioxidant role of carotenoids are discussed.

KEYWORDS:

Ciliary body and iris with stroma; Human fetal eye; Lens; Lutein; Lutein oxidized forms; Retina; Retinal pigment epithelium with choroid; Vitreous

PMID:
28454979
DOI:
10.1016/j.exer.2017.04.008
[Indexed for MEDLINE]

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