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Psychiatry Res. 2017 Jul;253:398-400. doi: 10.1016/j.psychres.2017.02.051. Epub 2017 Feb 27.

No association between SLC6A2, SLC6A3, DRD2 polymorphisms and schizophrenia in the Han Chinese population.

Author information

1
Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, China; Shanghai Institute of Mental Health, 600 South Wan Ping Road, Shanghai 200030, China.
2
Shanghai Institute of Mental Health, 600 South Wan Ping Road, Shanghai 200030, China.
3
Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, China; Institutes of Biomedical Sciences Fudan University, 138 Yixueyuan Road, Shanghai 200032, China; Institute for Nutritional Sciences, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China.
4
Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, China; Shanghai Institute of Mental Health, 600 South Wan Ping Road, Shanghai 200030, China. Electronic address: heguang@sjtu.edu.cn.

Abstract

This study was intended to ascertain whether SNPs in dopaminergic and serotoninergic pathway genes SLC6A2, SLC6A3 and DRD2 are associated with schizophrenia in Han Chinese people. We conducted a case-control study by genotyping 7 SNPs of the three genes in 1034 schizophrenia patients and 1034 controls. No significant difference in the allelic or genotypic frequency was detected between cases and controls despite one positive haplotype (rs1362621-rs2242446-rs5564). Stratified analysis of gender and gene-gene interaction analysis showed no positive results. In summary, our study denies the major role of these SNPs within the three genes for schizophrenia in Han Chinese.

KEYWORDS:

Association; SNP; Schizophrenia

PMID:
28454051
DOI:
10.1016/j.psychres.2017.02.051
[Indexed for MEDLINE]

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