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Curr Opin Neurobiol. 2017 Apr;43:177-186. doi: 10.1016/j.conb.2017.03.012. Epub 2017 Apr 25.

Synaptic plasticity in dendrites: complications and coping strategies.

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Biomedical Engineering Department and Neuroscience Graduate Program, University of Southern California, Los Angeles, CA 90089, United States. Electronic address:
Department of Physiology, The Rappaport Faculty of Medicine and Research Institute, Technion-Israel Institute of Technology, Haifa 35254, Israel.
Institute of Molecular Biology and Biotechnology (IMBB), Foundation for Research and Technology-Hellas (FORTH), Heraklion, Crete, Greece. Electronic address:


The elaborate morphology, nonlinear membrane mechanisms and spatiotemporally varying synaptic activation patterns of dendrites complicate the expression, compartmentalization and modulation of synaptic plasticity. To grapple with this complexity, we start with the observation that neurons in different brain areas face markedly different learning problems, and dendrites of different neuron types contribute to the cell's input-output function in markedly different ways. By committing to specific assumptions regarding a neuron's learning problem and its input-output function, specific inferences can be drawn regarding the synaptic plasticity mechanisms and outcomes that we 'ought' to expect for that neuron. Exploiting this assumption-driven approach can help both in interpreting existing experimental data and designing future experiments aimed at understanding the brain's myriad learning processes.

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