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J Infect Dis. 2017 Mar 15;215(6):933-937. doi: 10.1093/infdis/jix063.

Association Between Frailty and Components of the Frailty Phenotype With Modifiable Risk Factors and Antiretroviral Therapy.

Author information

1
Department of Medicine, University of Colorado-Anschutz Medical Campus, Aurora, USA.
2
Department of Schistosomiasis and Endemic Diseases , Wuhan City Center for Disease Prevention and Control , Wuhan , People's Republic of China.
3
Department of Internal Medicine, Ohio State University, Columbus.
4
Department of Medicine, MetroHealth Medical Center, Cleveland, Ohio, USA.
5
Department of Neurosciences, University of California-San Diego, USA.
6
Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
7
Department of Epidemiology, Harvard T. H. Chan, School of Public Health, Boston, Massachusetts, USA.

Abstract

The impact of antiretroviral therapy (ART) on frailty among human immunodeficiency virus (HIV)-infected adults has not been well described. HIV-infected participants aged ≥40 years with initial ART receipt through a randomized, controlled AIDS Clinical Trials Group trial completed a frailty assessment. Ordinal logistic regression models examined factors associated with frailty. Of 1016 participants, 6% were frail, and 38% were prefrail. Frailty was associated with lower education, older age, Medicare/Medicaid, initial efavirenz, smoking, obesity, and neurocognitive impairment; physical activity and alcohol use were protective. The associations with ART require further investigation, and associations between frailty and modifiable factors provide targets for future interventions.

KEYWORDS:

HIV; frail elderly; mobility limitation; muscle strength; antiretroviral therapy

PMID:
28453849
PMCID:
PMC5407051
DOI:
10.1093/infdis/jix063
[Indexed for MEDLINE]
Free PMC Article

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