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Mol Biol Evol. 2017 Aug 1;34(8):1890-1901. doi: 10.1093/molbev/msx125.

A-to-I RNA Editing in the Earliest-Diverging Eumetazoan Phyla.

Author information

1
The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel.
2
Global Change Institute, The University of Queensland, St Lucia, Australia.
3
Raymond and Beverly Sackler School of Physics and Astronomy, Tel Aviv University, Tel Aviv, Israel.
4
Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.
5
Eugene Bell Center for Regenerative Biology and Tissue Engineering, The Marine Biological Laboratory, Woods Hole, MA.

Abstract

The highly conserved ADAR enzymes, found in all multicellular metazoans, catalyze the editing of mRNA transcripts by the deamination of adenosines to inosines. This type of editing has two general outcomes: site specific editing, which frequently leads to recoding, and clustered editing, which is usually found in transcribed genomic repeats. Here, for the first time, we looked for both editing of isolated sites and clustered, non-specific sites in a basal metazoan, the coral Acropora millepora during spawning event, in order to reveal its editing pattern. We found that the coral editome resembles the mammalian one: it contains more than 500,000 sites, virtually all of which are clustered in non-coding regions that are enriched for predicted dsRNA structures. RNA editing levels were increased during spawning and increased further still in newly released gametes. This may suggest that editing plays a role in introducing variability in coral gametes.

KEYWORDS:

ADAR; RNA editing; coral; evolution

PMID:
28453786
PMCID:
PMC5850803
DOI:
10.1093/molbev/msx125
[Indexed for MEDLINE]
Free PMC Article

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