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PLoS One. 2017 Apr 28;12(4):e0176494. doi: 10.1371/journal.pone.0176494. eCollection 2017.

Altered resting-state intra- and inter- network functional connectivity in patients with persistent somatoform pain disorder.

Author information

1
MOE & Shanghai Key Laboratory of Brain Functional Genomics (East China Normal University), Institute of Cognitive Neuroscience, Shanghai Key Laboratory of Magnetic Resonance Institute of Cognitive Neuroscience, East China Normal University, Shanghai, China.
2
Department of General Psychiatry, Shanghai Changning Mental Health Center, Shanghai, China.
3
Department of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai, China.
4
Department of Psychiatry, HongKou District Mental Health Center of Shanghai, Shanghai, China.
5
Department of Psychiatry, Tongji Hospital of Tongji University, Shanghai, China.
6
Shanghai Key Laboratory of Brain Functional Genomics (MOE & STCSM), School of Psychology and Cognitive Science, East China Normal University, Shanghai, China.
7
Department of Psychiatry, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America.
8
MRI Unit, New York State Psychiatric Institute and Columbia University, New York, NY, United States of America.
9
Department of Psychological Medicine, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.

Abstract

Patients with persistent somatoform pain disorder (PSPD) usually experience various functional impairments in pain, emotion, and cognition, which cannot be fully explained by a physiological process or a physical disorder. However, it is still not clear for the mechanism underlying the pathogenesis of PSPD. The present study aimed to explore the intra- and inter-network functional connectivity (FC) differences between PSPD patients and healthy controls (HCs). Functional magnetic resonance imaging (fMRI) was performed in 13 PSPD patients and 23 age- and gender-matched HCs. We used independent component analysis on resting-state fMRI data to calculate intra- and inter-network FCs, and we used the two-sample t-test to detect the FC differences between groups. Spearman correlation analysis was employed to evaluate the correlations between FCs and clinical assessments. As compared to HCs, PSPD patients showed decreased coactivations in the right superior temporal gyrus within the anterior default-mode network and the anterior cingulate cortex within the salience network, and increased coactivations in the bilateral supplementary motor areas within the sensorimotor network and both the left posterior cingulate cortex and the medial prefrontal cortex within the anterior default-mode network. In addition, we found that the PSPD patients showed decreased FNCs between sensorimotor network and audio network as well as visual network, between default-mode network and executive control network as well as audio network and between salience network and executive control network as well as right frontoparietal network, and increased FNCs between sensorimotor network and left frontoparietal network, salience network as well as cerebellum network, which were negatively correlated with the clinical assessments in PSPD patients. Our findings suggest that PSPD patients experience large-scale reorganization at the level of the functional networks, which suggests a possible mechanism underlying the pathogenesis of PSPD.

PMID:
28453543
PMCID:
PMC5409184
DOI:
10.1371/journal.pone.0176494
[Indexed for MEDLINE]
Free PMC Article

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