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Nat Microbiol. 2017 Apr 28;2:17067. doi: 10.1038/nmicrobiol.2017.67.

Convergent evolution of a modified, acetate-driven TCA cycle in bacteria.

Author information

1
Department of Integrative Biology, University of Texas at Austin, Austin, Texas 78712, USA.

Abstract

The tricarboxylic acid (TCA) cycle is central to energy production and biosynthetic precursor synthesis in aerobic organisms. There are few known variations of a complete TCA cycle, with the common notion being that the enzymes involved have already evolved towards optimal performance. Here, we present evidence that an alternative TCA cycle, in which acetate:succinate CoA-transferase (ASCT) replaces the enzymatic step typically performed by succinyl-CoA synthetase (SCS), has arisen in diverse bacterial groups, including microbial symbionts of animals such as humans and insects.

PMID:
28452983
PMCID:
PMC5482284
DOI:
10.1038/nmicrobiol.2017.67
[Indexed for MEDLINE]
Free PMC Article

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