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Nat Commun. 2017 Apr 28;8:15172. doi: 10.1038/ncomms15172.

Antibiotic-producing symbionts dynamically transition between plant pathogenicity and insect-defensive mutualism.

Author information

1
Insect Symbiosis Research Group, Max Planck Institute for Chemical Ecology, Hans-Knöll-Straβe 8, 07745 Jena, Germany.
2
Department for Evolutionary Ecology, Institute of Organismic and Molecular Evolution, Johannes Gutenberg University, Johann-Joachim-Becher-Weg 13, 55128 Mainz, Germany.
3
Department of Biomolecular Chemistry, Leibniz Institute for Natural Products Research and Infection Biology, HKI, Beutenbergstraβe 11a, 07745 Jena, Germany.
4
Department of Biochemistry and Microbiology, UNESP-São Paulo State University, Av. 24A, n. 1515-Bela Vista, Rio Claro, São Paulo 13506-900, Brazil.
5
Chair for Natural Product Chemistry, Friedrich Schiller University, 07743 Jena, Germany.

Abstract

Pathogenic and mutualistic bacteria associated with eukaryotic hosts often lack distinctive genomic features, suggesting regular transitions between these lifestyles. Here we present evidence supporting a dynamic transition from plant pathogenicity to insect-defensive mutualism in symbiotic Burkholderia gladioli bacteria. In a group of herbivorous beetles, these symbionts protect the vulnerable egg stage against detrimental microbes. The production of a blend of antibiotics by B. gladioli, including toxoflavin, caryoynencin and two new antimicrobial compounds, the macrolide lagriene and the isothiocyanate sinapigladioside, likely mediate this defensive role. In addition to vertical transmission, these insect symbionts can be exchanged via the host plant and retain the ability to initiate systemic plant infection at the expense of the plant's fitness. Our findings provide a paradigm for the transition between pathogenic and mutualistic lifestyles and shed light on the evolution and chemical ecology of this defensive mutualism.

PMID:
28452358
PMCID:
PMC5414355
DOI:
10.1038/ncomms15172
[Indexed for MEDLINE]
Free PMC Article

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