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Cardiovasc Intervent Radiol. 2017 Sep;40(9):1454-1460. doi: 10.1007/s00270-017-1643-z. Epub 2017 Apr 27.

Human Thiel-Embalmed Cadaveric Aortic Model with Perfusion for Endovascular Intervention Training and Medical Device Evaluation.

Author information

1
Department of Metabolic and Clinical Medicine, Ninewells Hospital and Medical School, University of Dundee, Mailbox 1, Dundee, DD1 9SY, UK.
2
Institute for Medical Science and Technology, University of Dundee, Dundee, UK.
3
Centre for Anatomy and Human Identification, University of Dundee, Dundee, UK.
4
Department of Clinical Radiology, NHS Tayside, Dundee, UK.
5
Department of Metabolic and Clinical Medicine, Ninewells Hospital and Medical School, University of Dundee, Mailbox 1, Dundee, DD1 9SY, UK. j.g.houston@dundee.ac.uk.

Abstract

PURPOSE:

The purpose of this investigation was to evaluate human Thiel-embalmed cadavers with the addition of extracorporeal driven ante-grade pulsatile flow in the aorta as a model for simulation training in interventional techniques and endovascular device testing.

MATERIALS AND METHODS:

Three human cadavers embalmed according to the method of Thiel were selected. Extracorporeal pulsatile ante-grade flow of 2.5 L per min was delivered directly into the aorta of the cadavers via a surgically placed connection. During perfusion, aortic pressure and temperature were recorded and optimized for physiologically similar parameters. Pre- and post-procedure CT imaging was conducted to plan and follow up thoracic and abdominal endovascular aortic repair as it would be in a clinical scenario. Thoracic endovascular aortic repair (TEVAR) and endovascular abdominal repair (EVAR) procedures were conducted in simulation of a clinical case, under fluoroscopic guidance with a multidisciplinary team present.

RESULTS:

The Thiel cadaveric aortic perfusion model provided pulsatile ante-grade flow, with pressure and temperature, sufficient to conduct a realistic simulation of TEVAR and EVAR procedures. Fluoroscopic imaging provided guidance during the intervention. Pre- and post-procedure CT imaging facilitated planning and follow-up evaluation of the procedure.

CONCLUSION:

The human Thiel-embalmed cadavers with the addition of extracorporeal flow within the aorta offer an anatomically appropriate, physiologically similar robust model to simulate aortic endovascular procedures, with potential applications in interventional radiology training and medical device testing as a pre-clinical model.

KEYWORDS:

Cadaveric perfusion; Endovascular aortic aneurysm repair (EVAR); Endovascular training

PMID:
28451810
PMCID:
PMC5541076
DOI:
10.1007/s00270-017-1643-z
[Indexed for MEDLINE]
Free PMC Article

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