Format

Send to

Choose Destination
Cancer Immunol Immunother. 2017 Aug;66(8):1037-1048. doi: 10.1007/s00262-017-2003-1. Epub 2017 Apr 27.

Tumor-associated fibrosis as a regulator of tumor immunity and response to immunotherapy.

Jiang H1,2, Hegde S1,2, DeNardo DG3,4,5,6.

Author information

1
Department of Medicine, Washington University School of Medicine, 660 South Euclid Ave., Box 8069, St. Louis, MO, 63110, USA.
2
ICCE Institute, Washington University School of Medicine, St. Louis, MO, 63110, USA.
3
Department of Medicine, Washington University School of Medicine, 660 South Euclid Ave., Box 8069, St. Louis, MO, 63110, USA. ddenardo@dom.wustl.edu.
4
Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, 63110, USA. ddenardo@dom.wustl.edu.
5
ICCE Institute, Washington University School of Medicine, St. Louis, MO, 63110, USA. ddenardo@dom.wustl.edu.
6
Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO, 63110, USA. ddenardo@dom.wustl.edu.

Abstract

Tumor-associated fibrosis is characterized by unchecked pro-fibrotic and pro-inflammatory signaling. The components of fibrosis including significant numbers of cancer-associated fibroblasts, dense collagen deposition, and extracellular matrix stiffness, are well appreciated regulators of tumor progression but may also be critical regulators of immune surveillance. While this suggests that the efficacy of immunotherapy may be limited in highly fibrotic cancers like pancreas, it also suggests a therapeutic opportunity to target fibrosis in these tumor types to reawaken anti-tumor immunity. This review discusses the mechanisms by which fibrosis might subvert tumor immunity and how to overcome these mechanisms.

KEYWORDS:

Extracellular matrix; Fibrosis; Pancreas cancer; Regulatory myeloid suppressor cells; Tumor immunity; Tumor microenvironment

PMID:
28451791
PMCID:
PMC5603233
DOI:
10.1007/s00262-017-2003-1
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Springer Icon for PubMed Central
Loading ...
Support Center