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AJNR Am J Neuroradiol. 2017 Jun;38(6):1145-1150. doi: 10.3174/ajnr.A5173. Epub 2017 Apr 27.

Differentiation of Enhancing Glioma and Primary Central Nervous System Lymphoma by Texture-Based Machine Learning.

Author information

1
From the Departments of Medical Imaging (P.A.-L., A.B.) paulaalcaideleon@hotmail.com.
2
Department of Medical Imaging (P.D., A.F.G.) Toronto Western Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada.
3
Department of Medical Imaging (L.A.), Mount Sinai Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada.
4
Department of Medical Imaging (P.J.M.), Sunnybrook Research Institute, University of Toronto, Toronto, Ontario, Canada.
5
Neurosurgery (J.S.), St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.
6
From the Departments of Medical Imaging (P.A.-L., A.B.).

Abstract

BACKGROUND AND PURPOSE:

Accurate preoperative differentiation of primary central nervous system lymphoma and enhancing glioma is essential to avoid unnecessary neurosurgical resection in patients with primary central nervous system lymphoma. The purpose of the study was to evaluate the diagnostic performance of a machine-learning algorithm by using texture analysis of contrast-enhanced T1-weighted images for differentiation of primary central nervous system lymphoma and enhancing glioma.

MATERIALS AND METHODS:

Seventy-one adult patients with enhancing gliomas and 35 adult patients with primary central nervous system lymphomas were included. The tumors were manually contoured on contrast-enhanced T1WI, and the resulting volumes of interest were mined for textural features and subjected to a support vector machine-based machine-learning protocol. Three readers classified the tumors independently on contrast-enhanced T1WI. Areas under the receiver operating characteristic curves were estimated for each reader and for the support vector machine classifier. A noninferiority test for diagnostic accuracy based on paired areas under the receiver operating characteristic curve was performed with a noninferiority margin of 0.15.

RESULTS:

The mean areas under the receiver operating characteristic curve were 0.877 (95% CI, 0.798-0.955) for the support vector machine classifier; 0.878 (95% CI, 0.807-0.949) for reader 1; 0.899 (95% CI, 0.833-0.966) for reader 2; and 0.845 (95% CI, 0.757-0.933) for reader 3. The mean area under the receiver operating characteristic curve of the support vector machine classifier was significantly noninferior to the mean area under the curve of reader 1 (P = .021), reader 2 (P = .035), and reader 3 (P = .007).

CONCLUSIONS:

Support vector machine classification based on textural features of contrast-enhanced T1WI is noninferior to expert human evaluation in the differentiation of primary central nervous system lymphoma and enhancing glioma.

PMID:
28450433
DOI:
10.3174/ajnr.A5173
[Indexed for MEDLINE]
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