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Diabetes Care. 2017 Jul;40(7):981-984. doi: 10.2337/dc16-2598. Epub 2017 Apr 27.

Plasma Glycated CD59, a Novel Biomarker for Detection of Pregnancy-Induced Glucose Intolerance.

Author information

1
Division of Hematology, Brigham and Women's Hospital, Boston, MA.
2
Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, U.K.
3
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA.
4
Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Boston, MA.
5
Division of Maternal Fetal Medicine, Brigham and Women's Hospital, Boston, MA.
6
Division of Hematology, Brigham and Women's Hospital, Boston, MA jhalperin@bwh.harvard.edu.

Abstract

OBJECTIVE:

Plasma glycated CD59 (pGCD59) is an emerging biomarker in diabetes. We assessed whether pGCD59 could predict the following: the results of the glucose challenge test (GCT) for screening of gestational diabetes mellitus (GDM) (primary analysis); and the diagnosis of GDM and prevalence of large for gestational age (LGA) newborns (secondary analyses).

RESEARCH DESIGN AND METHODS:

Case-control study of 1,000 plasma samples from women receiving standard prenatal care, 500 women having a normal GCT (control subjects) and 500 women with a failed GCT and a subsequent oral glucose tolerance test (case patients).

RESULTS:

Compared with control subjects, the median (interquartile range) pGCD59 value was 8.5-fold higher in case patients and 10-fold higher in GDM patients, as follows: control subjects 0.33 (0.19); case patients 2.79 (1.4); GDM patients 3.23 (1.43) (P < 0.001); area under the receiver operating characteristic curve 0.92. LGA prevalence was 4.3% in the lowest quartile and 13.5% in the highest quartile of pGCD59.

CONCLUSIONS:

One pGCD59 measurement during weeks 24-28 identifies pregnancy-induced glucose intolerance with high sensitivity and specificity and can potentially identify the risk for LGA.

PMID:
28450368
PMCID:
PMC5481979
DOI:
10.2337/dc16-2598
[Indexed for MEDLINE]
Free PMC Article

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