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Adv Drug Deliv Rev. 2017 May 15;114:193-205. doi: 10.1016/j.addr.2017.04.012. Epub 2017 Apr 25.

Harnessing macrophage plasticity for tissue regeneration.

Author information

1
Department of Biomedical Engineering, University of California, Irvine, United States; Edwards Lifesciences Center for Advanced Cardiovascular Technology, University of California, Irvine, United States.
2
Edwards Lifesciences Center for Advanced Cardiovascular Technology, University of California, Irvine, United States; Department of Chemical Engineering and Materials Science, University of California, Irvine, United States.
3
Department of Biomedical Engineering, University of California, Irvine, United States; Edwards Lifesciences Center for Advanced Cardiovascular Technology, University of California, Irvine, United States; Department of Chemical Engineering and Materials Science, University of California, Irvine, United States. Electronic address: wendy.liu@uci.edu.

Abstract

Macrophages are versatile and plastic effector cells of the immune system, and contribute to diverse immune functions including pathogen or apoptotic cell removal, inflammatory activation and resolution, and tissue healing. Macrophages function as signaling regulators and amplifiers, and influencing their activity is a powerful approach for controlling inflammation or inducing a wound-healing response in regenerative medicine. This review discusses biomaterials-based approaches for altering macrophage activity, approaches for targeting drugs to macrophages, and approaches for delivering macrophages themselves as a therapeutic intervention.

KEYWORDS:

Biomaterials; Immunomodulation; Macrophage polarization; Nanoparticles; Wound healing

PMID:
28449872
DOI:
10.1016/j.addr.2017.04.012
[Indexed for MEDLINE]

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