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Cancer Genet. 2017 Apr;212-213:8-12. doi: 10.1016/j.cancergen.2017.03.003. Epub 2017 Mar 20.

Effects of polymorphisms identified in genome-wide association studies of never-smoking females on the prognosis of non-small cell lung cancer.

Author information

1
Departments of Internal Medicine, Kyungpook National University School of Medicine, Daegu, South Korea.
2
Biochemistry and Cell Biology, Kyungpook National University School of Medicine, Daegu, South Korea; Cell and Matrix Research Institute, Kyungpook National University School of Medicine, Daegu, South Korea.
3
Biochemistry and Cell Biology, Kyungpook National University School of Medicine, Daegu, South Korea.
4
Preventive Medicine, Kyungpook National University School of Medicine, Daegu, South Korea.
5
Thoracic Surgery, Kyungpook National University School of Medicine, Daegu, South Korea.
6
Center for Lung Cancer, National Cancer Center, Goyang, South Korea.
7
Lung and Esophageal Cancer Clinic, Chonnam National University Hwasun Hospital, Chonnam, South Korea.
8
Department of Thoracic and Cardiovascular Surgery, Seoul National University School of Medicine, Seoul, South Korea.
9
Department of Internal Medicine, Catholic University of Daegu, School of Medicine, Daegu, South Korea.
10
Department of Internal Medicine, Pusan National University School of Medicine, Busan, South Korea.
11
Departments of Internal Medicine, Kyungpook National University School of Medicine, Daegu, South Korea; Biochemistry and Cell Biology, Kyungpook National University School of Medicine, Daegu, South Korea. Electronic address: jaeyong@knu.ac.kr.

Abstract

A number of genome-wide association studies have reported several variants that influence the risk of lung cancer in never-smoking females. We evaluated the impact of these variants on survival outcome in never-smoking females with non-small cell lung cancer (NSCLC). In total, 510 never-smoking females with NSCLC who underwent curative surgery were enrolled. Eleven variants associated with lung cancer susceptibility in never-smoking females were genotyped and their associations with survival outcome were analyzed. Among these 11 variants, TP63 rs7631358 and CSF1R rs10079250 affected survival outcomes. TP63 rs7631358 G > A was associated with a relatively worse overall survival (under a dominant model; hazard ratio = 2.31, 95% confidence interval = 1.18-4.52, P = 0.01). CSF1R rs10079250 A > G was associated with a relatively better disease-free survival (under a codominant model; hazard ratio = 0.70, 95% confidence interval = 0.53-0.93, P = 0.01). These results suggest that TP63 rs7631358 G > A and CSF1R rs10079250 A > G may affect the prognosis of NSCLC in never-smoking females, as well as the risk of lung cancer.

KEYWORDS:

Non-small cell lung cancer; never-smoking females; polymorphism; survival outcomes

PMID:
28449811
DOI:
10.1016/j.cancergen.2017.03.003
[Indexed for MEDLINE]

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