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J Thorac Dis. 2017 Mar;9(3):796-801. doi: 10.21037/jtd.2017.03.13.

Clinicopathological features of Chinese lung cancer patients with epidermal growth factor receptor mutation.

Author information

1
Department of Thoracic Surgery, Shanghai Pulmonary Hospital affiliated Tongji University, Shanghai 200433, China.
2
Department of Thoracic Surgery, Tianjin Haihe Hospital, Tianjin 300350, China.
3
Department of Endodontics & Periodontics, College of Stomatology, Dalian Medical University, Dalian 116044, China.
4
Department of Thoracic surgery, Weihai Municipal Hospital, Weihai 264200, China.

Abstract

BACKGROUND:

Epidermal growth factor receptor (EGFR) gene was the major causative gene of lung cancer and also the specific treatment target. It is necessary to analyze the genotype and phenotype characters of patients.

METHODS:

We investigated 1,034 lung cancer patients in this study. The collected clinicopathological parameters included gender, age at diagnosis, smoking status, pathological TNM stage, tumor morphology and location, visceral pleural invasion as well as histological type.

RESULTS:

Almost 50% participants had EGFR mutations. L858R in exon 21 was the most common type. Concomitant mutation, 19 del and L858R, were detected in 20 patients. Compared to patients with exon 19 del or L858R mutations solely, they were inclined to have small size adenocarcinomas which occurred in bilateral and invaded the visceral pleura. The tyrosine kinases inhibitors (TKIs)-resistant mutation, insertions in exon 20, was detected in 11 patients.

CONCLUSIONS:

The summarized clinicopathological features will help clinicians to implement the feasible treatment plan.

KEYWORDS:

Lung cancer; epidermal growth factor receptor (EGFR) gene; genotype; mutation; phenotype

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