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Environ Pollut. 2017 Aug;227:1-7. doi: 10.1016/j.envpol.2017.04.054. Epub 2017 Apr 25.

Accumulative effects of indoor air pollution exposure on leukocyte telomere length among non-smokers.

Author information

1
Laboratory of Earth Surface Processes, College of Urban and Environmental Sciences, Peking University, Beijing, 100871, PR China.
2
Department of Respiratory and Critical Care Medicine, Peking University People's Hospital, Beijing 100044, PR China.
3
Intensive Care Unit, Beijing First Hospital of Integrated Chinese and Western Medicine, Beijing 100026, PR China.
4
Institute of Reproductive and Child Health, Peking University, Key Laboratory of Reproductive Health, National Health and Family Planning Commission of the People's Republic of China, Beijing 100191, PR China.
5
Laboratory of Earth Surface Processes, College of Urban and Environmental Sciences, Peking University, Beijing, 100871, PR China. Electronic address: taos@pku.edu.cn.

Abstract

Indoor air pollution is an important environmental factor that contributes to the burden of various diseases. Long-term exposure to ambient air pollution is associated with telomere shortening. However, the association between chronic indoor air pollution from household fuel combustion and leukocyte telomere length has not been studied. In our study, 137 cancer-free non-smokers were recruited. Their exposure levels to indoor air pollution from 1985 to 2014 were assessed using a face-to-face interview questionnaire, and leukocyte telomere length (LTL) was measured using a monochrome multiplex quantitative PCR method. Accumulative exposure to solid fuel usage for cooking was negatively correlated with LTL. The LTL of residents who were exposed to solid fuel combustion for three decades (LTL = 0.70 ± 0.17) was significantly shorter than that of other populations. In addition, education and occupation were related to both exposure to solid fuel and LTL. Sociodemographic factors may play a mediating role in the correlation between leukocyte telomere length and environmental exposure to indoor air pollution. In conclusion, long-term exposure to indoor air pollution may cause LTL dysfunction.

KEYWORDS:

Accumulative effects; Indoor air pollution; Leukocyte telomere length; Main finding; Solid fuel combustion

PMID:
28448823
DOI:
10.1016/j.envpol.2017.04.054
[Indexed for MEDLINE]

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