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PLoS One. 2017 Apr 27;12(4):e0174282. doi: 10.1371/journal.pone.0174282. eCollection 2017.

Association between vitamin D deficiency and health-related quality of life in patients with chronic kidney disease from the KNOW-CKD study.

Author information

1
Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea.
2
Depatment of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
3
Department of Internal Medicine, Eulji University, Seoul, Korea.
4
Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University, Seoul, Korea.
5
Department of Internal Medicine, Seoul National University, Seoul, Korea.

Abstract

Vitamin D deficiency is a growing health problem in both the general population and in patients with chronic kidney disease (CKD). However, the relationship between serum 25-hydroxyvitamin D levels and health-related quality of life in CKD is not well established. This study examined the association between vitamin D deficiency and quality of life in pre-dialysis CKD patients. Serum 25-hydroxyvitamin D levels and the Korean version of the Kidney Disease Quality of Life short form were obtained for 1844 pre-dialysis CKD patients in the prospective KoreaN cohort Study for Outcomes in patients With Chronic Kidney Disease (KNOW-CKD). The baseline estimated glomerular filtration rate was 50.26 ± 0.71 mL/min/1.73 m2. We identified 1294 (70.2%) patients with vitamin D deficiency, defined as a 25-hydroxyvitamin D level < 20 ng/ml. The scores of the kidney disease component summary, physical component summary, and mental component summary in the vitamin D deficiency group were significantly lower compared to the scores of those without vitamin D deficiency. The serum 25-hydroxyvitamin D level was independently associated with the kidney disease component summary and mental component summary scores (β = 0.147, p = 0.003 and β = 0.151, p = 0.047). In conclusion, there was a significant association between serum 25-hydroxyvitamin D levels and kidney disease component summary and mental component summary scores in pre-dialysis CKD patients.

PMID:
28448520
PMCID:
PMC5407618
DOI:
10.1371/journal.pone.0174282
[Indexed for MEDLINE]
Free PMC Article

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