Format

Send to

Choose Destination
Clin Exp Hypertens. 2017;39(3):220-224. doi: 10.1080/10641963.2016.1235182.

Estrogen receptor alpha XbaI GG genotype was associated with severe preeclampsia.

Author information

1
a Cellular and Molecular Research Center, Zahedan University of Medical Sciences , Zahedan , Iran.
2
b Department of Clinical Biochemistry , School of Medicine, Zahedan University of Medical Sciences , Zahedan , Iran.
3
c Department of Pharmacology , School of Medicine, Zahedan University of Medical Sciences , Zahedan , Iran.
4
d Department of Biostatistics and Epidemiology , School of Public Health, Zahedan University of Medical Sciences , Zahedan , Iran.
5
e Department of Obstetrics and Gynecology , School of Medicine, Shahid Beheshti University of Medical Sciences , Tehran , Iran.
6
f Department of Obstetrics and Gynecology , School of Medicine, Zahedan University of Medical Sciences , Zahedan , Iran.

Abstract

PURPOSE:

Estrogen receptor-α (ERα) plays an essential role in the adaptation of increased uterine blood flow during gestation. Therefore, ERα gene could be a possible candidate for preeclampsia (PE) susceptibility. In current study we aimed to investigate the association of the ERα gene polymorphisms and PE in an Iranian population.

METHODS:

A total of 192 pregnant women with PE and 186 normotensive women were genotyped for ERα gene (PvuII and XbaI) polymorphisms by polymerase chain reaction-restriction fragment length polymorphism method.

RESULTS:

The frequencies of alleles and genotypes of ERα PvuII and XbaI polymorphisms were not different between PE and normotensive control women. However, higher frequency of GG genotype was observed in women with severe PE compared to mild PE (OR, 1.8 [95% CI, 1.1 to 3]; p = 0.02) and in severe PE compared to normotensive women [OR = 1.8 (1.1-3), p = 0.02] after adjusting for age, ethnicity, and primiparity.

CONCLUSIONS:

The GG genotype of ERα XbaI polymorphism could be a genetic risk factor for PE predisposition.

KEYWORDS:

Estrogen receptor-α; Iran; gene; polymorphism; preeclampsia; severe

PMID:
28448182
DOI:
10.1080/10641963.2016.1235182
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Taylor & Francis
Loading ...
Support Center