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J Nutr Health Aging. 2017;21(5):562-566. doi: 10.1007/s12603-016-0806-y.

Effect of a Mediterranean Type Diet on Inflammatory and Cartilage Degradation Biomarkers in Patients with Osteoarthritis.

Author information

1
Dr. Alexis R. Mauger, School of Sport and Exercise Sciences, The Medway Campus, University of Kent, KENT, ME4 4AG, United Kingdom, Telephone: +44 (0)1634 888997, Fax: +44 (0)1634 888890, Email: L.Mauger@kent.ac.uk.

Abstract

OBJECTIVES:

To investigate the effects of a Mediterranean type diet on patients with osteoarthritis (OA).

PARTICIPANTS:

Ninety-nine volunteers with OA (aged 31 - 90 years) completed the study (83% female).

SETTING:

Southeast of England, UK.

DESIGN:

Participants were randomly allocated to the dietary intervention (DIET, n = 50) or control (CON, n = 49). The DIET group were asked to follow a Mediterranean type diet for 16 weeks whereas the CON group were asked to follow their normal diet.

MEASUREMENTS:

All participants completed an Arthritis Impact Measurement Scale (AIMS2) pre-, mid- and post- study period. A subset of participants attended a clinic at the start and end of the study for assessment of joint range of motion, ROM (DIET = 33, CON = 28), and to provide blood samples (DIET = 29, CON = 25) for biomarker analysis (including serum cartilage oligomeric matrix protein (sCOMP) (a marker of cartilage degradation) and a panel of other relevant biomarkers including pro- and anti-inflammatory cytokines).

RESULTS:

There were no differences between groups in the response of any AIMS2 components and most biomarkers (p > 0.05), except the pro-inflammatory cytokine IL-1α, which decreased in the DIET group (~47%, p = 0.010). sCOMP decreased in the DIET group by 1 U/L (~8%, p = 0.014). There was a significant improvement in knee flexion and hip rotation ROM in the DIET group (p < 0.05).

CONCLUSIONS:

The average reduction in sCOMP in the DIET group (1 U/L) represents a meaningful change, but the longer term effects require further study.

KEYWORDS:

AIMS2; Diet; IL-1α; Mediterranean diet; osteoarthritis (OA); sCOMP

PMID:
28448087
PMCID:
PMC5405095
DOI:
10.1007/s12603-016-0806-y
[Indexed for MEDLINE]
Free PMC Article

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