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Nat Commun. 2017 Apr 27;8:14997. doi: 10.1038/ncomms14997.

Wearable smart sensor systems integrated on soft contact lenses for wireless ocular diagnostics.

Author information

1
School of Materials Science and Engineering, School of Energy and Chemical Engineering, Wearable Electronics Research Group, Center for Smart Sensor Systems, Ulsan National Institute of Science and Technology (UNIST), Ulsan 44919, Republic of Korea.
2
School of Life Sciences, School of Energy and Chemical Engineering, Ulsan National Institute of Science and Technology (UNIST), Ulsan 44919, Republic of Korea.
3
School of Electrical and Computer Engineering, Ulsan National Institute of Science and Technology (UNIST), Ulsan 44919, Republic of Korea.
4
Division of Endocrinology, Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu 41944, Republic of Korea.
5
Department of Ophthalmology, Kyungpook National University School of Medicine, Daegu 41944, Republic of Korea.

Abstract

Wearable contact lenses which can monitor physiological parameters have attracted substantial interests due to the capability of direct detection of biomarkers contained in body fluids. However, previously reported contact lens sensors can only monitor a single analyte at a time. Furthermore, such ocular contact lenses generally obstruct the field of vision of the subject. Here, we developed a multifunctional contact lens sensor that alleviates some of these limitations since it was developed on an actual ocular contact lens. It was also designed to monitor glucose within tears, as well as intraocular pressure using the resistance and capacitance of the electronic device. Furthermore, in-vivo and in-vitro tests using a live rabbit and bovine eyeball demonstrated its reliable operation. Our developed contact lens sensor can measure the glucose level in tear fluid and intraocular pressure simultaneously but yet independently based on different electrical responses.

PMID:
28447604
PMCID:
PMC5414034
DOI:
10.1038/ncomms14997
[Indexed for MEDLINE]
Free PMC Article

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