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J Thromb Thrombolysis. 2017 Jul;44(1):63-66. doi: 10.1007/s11239-017-1502-4.

Retinal vein occlusion and paroxysmal nocturnal hemoglobinuria.

Author information

1
Hematology Laboratory (Division of Thrombosis and Hemostasis), ICO-Badalona, Hospital Germans Trias i Pujol, Josep Carreras Leukemia Research Institute, Universitat Autonoma de Barcelona, Ctra. Canyet s/n, 08916, Badalona, Spain. mc.sorigue@zoho.com.
2
Hematology Laboratory, ICO-Badalona, Hospital Germans Trias i Pujol, Josep Carreras Leukemia Research Institute, Universitat Autonoma de Barcelona, Badalona, Spain.
3
Department of Ophthalmology, Hospital Germans Trias i Pujol, Universitat Autonoma de Barcelona, Badalona, Spain.
4
Department of Hematology, Hospital Germans Trias i Pujol, Universitat Autonoma de Barcelona, Badalona, Spain.

Abstract

Paroxysmal nocturnal hemoglobinuria (PNH) is a rare disorder associated with increased risk for thrombosis and reduced life expectancy. Retinal vein occlusion (RVO) is a frequent cause of vision loss but its relationship with PNH has not been studied systematically. Patients followed up for RVO in our ophthalmology department were screened for the presence of a PNH clone in peripheral blood by means of flow cytometry. The presence of other well-documented risk factors for RVO was also analyzed. In a series of 110 patients (54 males, median age of 67) we found no evidence of PNH. Most patients (97/110) had cardiovascular risk factors and/or hyperhomocysteinemia (67/110). Inherited thrombophilias were rare (three confirmed cases). Therefore, PNH does not appear to play a role in the development of RVO. However, this finding does not necessarily apply to young patients and/or those with no conventional risk factors for RVO, due to the low number of patients in these subgroups in our population.

KEYWORDS:

Flow cytometry; Paroxysmal nocturnal hemoglobinuria; Retinal vein occlusion; Thrombophilia

PMID:
28447244
DOI:
10.1007/s11239-017-1502-4
[Indexed for MEDLINE]

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