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Front Immunol. 2017 Apr 12;8:400. doi: 10.3389/fimmu.2017.00400. eCollection 2017.

Clinical Evidence for the Microbiome in Inflammatory Diseases.

Author information

1
Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
2
Department of Genomic Medicine, Division of Cancer Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
3
Department of Stem Cell Transplantation Cellular Therapy, Division of Cancer Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Abstract

Clinical evidence is accumulating for a role of the microbiome in contributing to or modulating severity of inflammatory diseases. These studies can be organized by various organ systems involved, as well as type of study approach utilized, whether investigators compared the microbiome of cases versus controls, followed patients longitudinally, or intervened with antibiotics, prebiotics, or bacterial introduction. In this review, we summarize the clinical evidence supporting the microbiome as an important mechanism in the onset and maintenance of inflammation.

KEYWORDS:

autoimmune diseases; bacteria; inflammation; microbiome; microbiota

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