Format

Send to

Choose Destination
Neurology. 2017 May 23;88(21):1996-2002. doi: 10.1212/WNL.0000000000003961. Epub 2017 Apr 26.

Vagotomy and Parkinson disease: A Swedish register-based matched-cohort study.

Author information

1
From the Departments of Medical Epidemiology and Biostatistics (B.L., F.F., N.L.P., A.T., J.F.L., K.W.), Medicine (A.E.), and Clinical Neuroscience (P.S., K.W.), Karolinska Institutet, Stockholm, Sweden; Department of Psychology (N.L.P.), University of Southern California, Los Angeles; Department of Paediatrics (J.F.L.), Örebro University Hospital, Sweden; and Department of Epidemiology and Biostatistics (H.C.), College of Human Medicine, Michigan State University, East Lansing. bojing.liu@ki.se.
2
From the Departments of Medical Epidemiology and Biostatistics (B.L., F.F., N.L.P., A.T., J.F.L., K.W.), Medicine (A.E.), and Clinical Neuroscience (P.S., K.W.), Karolinska Institutet, Stockholm, Sweden; Department of Psychology (N.L.P.), University of Southern California, Los Angeles; Department of Paediatrics (J.F.L.), Örebro University Hospital, Sweden; and Department of Epidemiology and Biostatistics (H.C.), College of Human Medicine, Michigan State University, East Lansing.

Abstract

OBJECTIVE:

To examine whether vagotomy decreases the risk of Parkinson disease (PD).

METHODS:

Using data from nationwide Swedish registers, we conducted a matched-cohort study of 9,430 vagotomized patients (3,445 truncal and 5,978 selective) identified between 1970 and 2010 and 377,200 reference individuals from the general population individually matched to vagotomized patients by sex and year of birth with a 40:1 ratio. Participants were followed up from the date of vagotomy until PD diagnosis, death, emigration out of Sweden, or December 31, 2010, whichever occurred first. Vagotomy and PD were identified from the Swedish Patient Register. We estimated hazard ratios (HRs) with 95% confidence intervals (CIs) using Cox models stratified by matching variables, adjusting for country of birth, chronic obstructive pulmonary disease, diabetes mellitus, vascular diseases, rheumatologic disease, osteoarthritis, and comorbidity index.

RESULTS:

A total of 4,930 cases of incident PD were identified during 7.3 million person-years of follow-up. PD incidence (per 100,000 person-years) was 61.8 among vagotomized patients (80.4 for truncal and 55.1 for selective) and 67.5 among reference individuals. Overall, vagotomy was not associated with PD risk (HR 0.96, 95% CI 0.78-1.17). However, there was a suggestion of lower risk among patients with truncal vagotomy (HR 0.78, 95% CI 0.55-1.09), which may be driven by truncal vagotomy at least 5 years before PD diagnosis (HR 0.59, 95% CI 0.37-0.93). Selective vagotomy was not related to PD risk in any analyses.

CONCLUSIONS:

Although overall vagotomy was not associated the risk of PD, we found suggestive evidence for a potential protective effect of truncal, but not selective, vagotomy against PD development.

PMID:
28446653
PMCID:
PMC5440238
DOI:
10.1212/WNL.0000000000003961
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center