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Cancer Epidemiol Biomarkers Prev. 2017 Aug;26(8):1276-1287. doi: 10.1158/1055-9965.EPI-16-1006. Epub 2017 Apr 26.

A Pooled Analysis of 15 Prospective Cohort Studies on the Association between Fruit, Vegetable, and Mature Bean Consumption and Risk of Prostate Cancer.

Author information

1
Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts. jsp778@mail.harvard.edu pooling@hsph.harvard.edu.
2
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
3
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
4
Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
5
Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
6
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland.
7
Department of Epidemiology, GROW-School for Oncology and Developmental Biology, Maastricht University, Maastricht, the Netherlands.
8
Cancer Epidemiology Centre, Cancer Council Victoria, Carlton, Victoria, Australia.
9
Department of Medicine, Harvard Medical School, Boston, Massachusetts.
10
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington.
11
SWOG Statistical Center, Seattle, Washington.
12
Division of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
13
Division of Cancer Control and Population Sciences, National Cancer Institute, NIH, Bethesda, Maryland.
14
Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.
15
Department of Public Health Sciences, University of Hawaii, Honolulu, Hawaii.
16
Department of Health, National Institute for Health and Welfare, Helsinki, Finland.
17
Epidemiology Research Program, American Cancer Society, Atlanta, Georgia.
18
Division of Public Health Sciences, Washington University School of Medicine, St. Louis, Missouri.
19
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
20
School of Public Health, Imperial College London, London, United Kingdom.
21
Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan.
22
Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii.

Abstract

Background: Relationships between fruit, vegetable, and mature bean consumption and prostate cancer risk are unclear.Methods: We examined associations between fruit and vegetable groups, specific fruits and vegetables, and mature bean consumption and prostate cancer risk overall, by stage and grade, and for prostate cancer mortality in a pooled analysis of 15 prospective cohorts, including 52,680 total cases and 3,205 prostate cancer-related deaths among 842,149 men. Diet was measured by a food frequency questionnaire or similar instrument at baseline. We calculated study-specific relative risks using Cox proportional hazards regression, and then pooled these estimates using a random effects model.Results: We did not observe any statistically significant associations for advanced prostate cancer or prostate cancer mortality with any food group (including total fruits and vegetables, total fruits, total vegetables, fruit and vegetable juice, cruciferous vegetables, and tomato products), nor specific fruit and vegetables. In addition, we observed few statistically significant results for other prostate cancer outcomes. Pooled multivariable relative risks comparing the highest versus lowest quantiles across all fruit and vegetable exposures and prostate cancer outcomes ranged from 0.89 to 1.09. There was no evidence of effect modification for any association by age or body mass index.Conclusions: Results from this large, international, pooled analysis do not support a strong role of collective groupings of fruits, vegetables, or mature beans in prostate cancer.Impact: Further investigation of other dietary exposures, especially indicators of bioavailable nutrient intake or specific phytochemicals, should be considered for prostate cancer risk. Cancer Epidemiol Biomarkers Prev; 26(8); 1276-87. ©2017 AACR.

PMID:
28446545
PMCID:
PMC5540798
DOI:
10.1158/1055-9965.EPI-16-1006
[Indexed for MEDLINE]
Free PMC Article

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