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Prog Neuropsychopharmacol Biol Psychiatry. 2017 Jul 3;77:222-227. doi: 10.1016/j.pnpbp.2017.04.029. Epub 2017 Apr 23.

Resting-state functional connectivity of the amygdala in suicide attempters with major depressive disorder.

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Department of Psychiatry, Gil Medical Center, Gachon University, School of Medicine, Incheon, Republic of Korea.
Department of Neuropsychiatry, Eulji University School of Medicine, Eulji General Hospital, Seoul, Republic of Korea.
Research Institute for Advanced Industrial Technology, College of Science and Technology, Korea University, Republic of Korea.
Department of Biomedical Engineering, College of Health Science, Gachon University, Incheon, Republic of Korea. Electronic address:
Department of Psychiatry, Center for Sleep and Chronobiology, Seoul National University College of Medicine, Seoul, Republic of Korea. Electronic address:


In this study, we investigated the difference in resting-state functional connectivity (RSFC) of the amygdala between suicide attempters and non-suicide attempters with major depressive disorder (MDD) using functional magnetic resonance imaging (fMRI). This study included 19 suicide attempters with MDD and 19 non-suicide attempters with MDD. RSFC was compared between the two groups and the regression analyses were conducted to identify the correlation between RSFC and Scale for Suicide Ideation (SSI) scores in the suicide attempt group. Statistical significance was set at p-value (uncorrected) <0.005 with k≥28 voxels. Compared with non-suicide attempters, suicide attempters showed significantly increased RSFC of the left amygdala with the right insula and left superior orbitofrontal area, and increased RSFC of the right amygdala with the left middle temporal area. The regression analysis showed a significant correlation between the SSI total score and RSFC of the right amygdala with the right parahippocampal area in the suicide attempt group. The present RSFC findings provide evidence of a functional neural basis and will help reveal the pathophysiology underlying suicidality in subjects with MDD.


Amygdala; Major depressive disorder; Resting state functional connectivity; Suicide attempt; fMRI

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