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Chem Biol Interact. 2017 Jun 1;271:9-14. doi: 10.1016/j.cbi.2017.04.017. Epub 2017 Apr 22.

Zerumbone reduced the inflammatory response of acute lung injury in endotoxin-treated mice via Akt-NFκB pathway.

Author information

1
School of Medical Applied Chemistry, Chung Shan Medical University, Taichung, Taiwan.
2
School of Public Health, Chung Shan Medical University, Taichung, Taiwan.
3
Department of Anatomy, School of Medicine, Chung Shan Medical University, Taichung, Taiwan.
4
School of Nutrition, Chung Shan Medical University, Taichung, Taiwan.
5
Department of Pharmacology, School of Medicine, Chung Shan Medical University, Taichung, Taiwan; Department of Pharmacy, Chung Shan Medical University Hospital, Taichung, Taiwan.
6
Department of Pharmacology, School of Medicine, Chung Shan Medical University, Taichung, Taiwan; Department of Pharmacy, Chung Shan Medical University Hospital, Taichung, Taiwan. Electronic address: kuanyh@csmu.edu.tw.

Abstract

Zerumbone, a cyclic eleven-membered sesquiterpene, is the major component of the essential oil isolated from the wild ginger, Zingiber zerumbet. There are several beneficial pharmacological activities of zerumbone including anti-inflammatory, antioxidant, and anticancer activities. Acute lung injury (ALI) is an acute pulmonary inflammatory disorder with high morbidity and mortality rate. In present study, we aimed to investigate the protective effects and mechanisms of zerumbone on endotoxin, lipopolysaccharide (LPS)-induced ALI. Mice were pretreated with zerumbone at various concentrations for 30 min followed by intratracheal administration of LPS for 6 h. Pretreatment with zerumbone not only reduced leukocytes infiltration into the alveolar space but also inhibited lung edema in LPS-induced ALI. Decreased secretion of proinflammatory cytokines such as TNFα and IL-6 caused by LPS were reversed by zerumbone. LPS-induced expressions of proinflammatory mediators, iNOS and COX-2, were inhibited by zerumbone. In addition, NFκB activation and Akt phosphorylation were inhibited by zerumbone in LPS-induced ALI. All these results suggested that the protective mechanisms of zerumbone on endotoxin-induced ALI were via inhibition of Akt-NFκB activation.

KEYWORDS:

Acute lung injury; Akt-NFκB; Endotoxin; Proinflammatory mediators; Zerumbone

PMID:
28442377
DOI:
10.1016/j.cbi.2017.04.017
[Indexed for MEDLINE]

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