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Nutrients. 2017 Apr 23;9(4). pii: E420. doi: 10.3390/nu9040420.

Associations between Diet and Toenail Arsenic Concentration among Pregnant Women in Bangladesh: A Prospective Study.

Author information

1
Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA 02113, USA. pil864@mail.harvard.edu.
2
Research Center for Environmental Medicine, Kaohsiung Medical University, Kaohsiung 80709, Taiwan. pil864@mail.harvard.edu.
3
Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA 02113, USA. sbromage@mail.harvard.edu.
4
Department of Environmental Research, Dhaka Community Hospital, Dhaka 1217, Bangladesh. mostofa07@gmail.com.
5
Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA 02113, USA. jgallen@hsph.harvard.edu.
6
Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA 02115, USA. emily_oken@harvardpilgrim.org.
7
Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA 02113, USA. molly.kile@oregonstate.edu.
8
Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA 02113, USA. dchris@hsph.harvard.edu.
9
Research Center for Environmental Medicine, Kaohsiung Medical University, Kaohsiung 80709, Taiwan. dchris@hsph.harvard.edu.

Abstract

This prospective study evaluated the relationship between long-term dietary habits and total arsenic (As) concentration in toenail clippings in a cohort of 1616 pregnant women in the Bangladeshi administrative regions of Sirajdikhan and Pabna Sadar. Diet was assessed at Gestation Week 28 and at Postpartum Month 1, using a locally-validated dish-based semi-quantitative food-frequency questionnaire. Toenail As concentration was analyzed by microwave-assisted acid digestion and inductively coupled plasma mass spectrometry. Associations between natural log-transformed consumption of individual food items and temporally matched natural log-transformed toenail As concentration were quantified using general linear models that accounted for As concentration in the primary drinking water source and other potential confounders. The analysis was stratified by As in drinking water (≤50 μg/L versus >50 μg/L) and the time of dietary assessment (Gestation Week 28 versus Postpartum Week 1). Interestingly, toenail As was not significantly associated with consumption of plain rice as hypothesized. However, toenail As was positively associated with consumption of several vegetable, fish and meat items and was negatively associated with consumption of rice, cereal, fruits, and milk based food items. Further studies in pregnant women are needed to compare As metabolism at different levels of As exposure and the interaction between dietary composition and As absorption.

KEYWORDS:

Bangladesh; arsenic exposure; dietary assessment; food frequency questionnaire; pregnancy

PMID:
28441747
PMCID:
PMC5409759
DOI:
10.3390/nu9040420
[Indexed for MEDLINE]
Free PMC Article

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