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Annu Rev Neurosci. 2017 Jul 25;40:307-325. doi: 10.1146/annurev-neuro-072116-031121. Epub 2017 Apr 24.

Nerve Growth Factor and Pain Mechanisms.

Author information

1
Neurorestoration Group, Wolfson Centre for Age-Related Diseases, King's College London, London SE1 1UL, United Kingdom; email: stephen.mcmahon@kcl.ac.uk.
2
Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, United Kingdom.

Abstract

Nerve growth factor (NGF) antagonism is on the verge of becoming a powerful analgesic treatment for numerous conditions, including osteoarthritis and lower back pain. This review summarizes the historical research, both fundamental and clinical, that led to our current understanding of NGF biology. We also discuss the surprising number of questions that remain about NGF expression patterns and NGF's various functions and interaction partners in relation to persistent pain and the potential side effects of anti-NGF therapy.

KEYWORDS:

chronic pain; nerve growth factor; p75; trkA

[Indexed for MEDLINE]

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