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Rev Med Inst Mex Seguro Soc. 2017 May-Jun;55(3):362-373.

[Autoimmune/inflammatory syndrome induced by adjuvants. A new clinical entity?]

[Article in Spanish; Abstract available in Spanish from the publisher]

Author information

Departamento de Inmunología, Hospital Clínico-Quirúrgico "Saturnino Lora", Santiago de Cuba, Cuba.


in English, Spanish

Recently Shoenfeld and Agmon-Levin proposed a new clinical entity called autoimmune/inflammatory syndrome induced by adjuvants (ASIA), which includes four clinical entities called: 1) siliconosis, 2) Gulf War syndrome, 3) macrophage myofasciitis) and 4) post-vaccination phenomenon associated with adjuvants. They all have a common denominator: a prior exposure to immunoadjuvants, and, in addition, they also share several clinical criteria associated to chronic inflammation and autoimmune reactions. This proposal still needs to be validated by the scientific community, but nowadays is a topic of hot discussion in the literature and in various international conferences. In this revision article, we analyze the characteristics of this syndrome, the current mechanisms possibly involved in the pathogenesis, and the more recent reports regarding ASIA associated to vaccine and some foreign substances.


Autoimmunity; Immunologic adjuvants

[Indexed for MEDLINE]

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