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Rev Med Inst Mex Seguro Soc. 2017 May-Jun;55(3):341-352.

[How safe is the recombinant human growth hormone?]

[Article in Spanish; Abstract available in Spanish from the publisher]

Author information

Servicio de Endocrinología, Instituto Nacional de Pediatría, Secretaría de Salud, Ciudad de México, México.


in English, Spanish

In this paper, several aspects related to the safety of the use of biosynthetic human growth hormone are reviewed. For example, its classification as a biosynthetic drug, the phases that need to be performed in Mexico to verify its safety (obtaining, purification, preclinical studies, clinical trials, and finally observational clinical studies), as well as the evidence that exists in relation to the association of intracranial hypertension, muscular events, scoliosis, slipped capital femoral epiphysis, obstructive sleep apnea, pancreatitis, alterations in cortisol, thyroid hormones alterations, cardiovascular disease, metabolic risk, mortality and cancer, adverse events not related to its use, and finally dosing and safety.


Hormona del crecimiento; Seguridad

[Indexed for MEDLINE]

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