Format

Send to

Choose Destination
Obesity (Silver Spring). 2017 May;25(5):892-900. doi: 10.1002/oby.21815.

Attenuated Low-Grade Inflammation Following Long-Term Dietary Intervention in Postmenopausal Women with Obesity.

Author information

1
Department of Public Health and Clinical Medicine, Faculty of Medicine, Umeå University, Umeå, Sweden.
2
Department of Food and Nutrition and Sport Science, University of Gothenburg, Gothenburg, Sweden.
3
Department of Public Health and Clinical Medicine, Occupational and Environmental Medicine, Umeå University, Umeå, Sweden.

Abstract

OBJECTIVE:

Abdominal fat accumulation after menopause is associated with low-grade inflammation and increased risk of metabolic disorders. Effective long-term lifestyle treatment is therefore needed.

METHODS:

Seventy healthy postmenopausal women (age 60 ± 5.6 years) with BMI 32.5 ± 5.5 were randomized to a Paleolithic-type diet (PD) or a prudent control diet (CD) for 24 months. Blood samples and fat biopsies were collected at baseline, 6 months, and 24 months to analyze inflammation-related parameters.

RESULTS:

Android fat decreased significantly more in the PD group (P = 0.009) during the first 6 months with weight maintenance at 24 months in both groups. Long-term significant effects (P < 0.001) on adipose gene expression were found for toll-like receptor 4 (decreased at 24 months) and macrophage migration inhibitory factor (increased at 24 months) in both groups. Serum interleukin 6 (IL-6) and tumor necrosis factor α levels were decreased at 24 months in both groups (P < 0.001) with a significant diet-by-time interaction for serum IL-6 (P = 0.022). High-sensitivity C-reactive protein was decreased in the PD group at 24 months (P = 0.001).

CONCLUSIONS:

A reduction of abdominal obesity in postmenopausal women is linked to specific changes in inflammation-related adipose gene expression.

TRIAL REGISTRATION:

ClinicalTrials.gov NCT00692536.

PMID:
28440046
DOI:
10.1002/oby.21815
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center