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J Neurovirol. 2017 Aug;23(4):615-620. doi: 10.1007/s13365-017-0525-0. Epub 2017 Apr 24.

Parsonage-Turner syndrome due to autochthonous acute genotype 3f hepatitis E virus infection in a nonimmunocompromised 55-year-old patient.

Author information

1
Virology Laboratory, University Hospital of Strasbourg, F-67000, Strasbourg, France. Aurelie.velay@chru-strasbourg.fr.
2
INSERM, IRM UMR-S 1109, F-67000, Strasbourg, France. Aurelie.velay@chru-strasbourg.fr.
3
Virology Laboratory, University Hospital of Strasbourg, F-67000, Strasbourg, France.
4
INSERM, IRM UMR-S 1109, F-67000, Strasbourg, France.
5
INSERM, U1043, Centre de Physiopathologie de Toulouse Purpan, F-31300, Toulouse, France.
6
CHU Toulouse Hôpital Purpan, Laboratoire de virologie, Institut fédératif de biologie de Purpan, F-31300, Toulouse, France.
7
Department of Neuroradiology, University Hospital of Strasbourg, F-67098, Strasbourg, France.
8
Service de Neurologie, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.
9
Biopathologie de la Myéline, Neuroprotection et Stratégies Thérapeutiques, UMR_S INSERM U1119, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg, Strasbourg, France.
10
Department of Gastroenterology and Hepatology, University Hospital of Strasbourg, F-67098, Strasbourg, France.

Abstract

Hepatitis E virus (HEV) infection is an emerging autochthonous disease in industrialized countries. Extra-hepatic manifestations, in particular neurologic manifestations, have been reported in HEV infection. Only a few cases of hepatitis E-associated Parsonage-Turner syndrome have been reported, and HEV genotypes were rarely determined. Here, we report the case of a Parsonage-Turner syndrome associated with an acute autochthonous HEV infection in a 55-year-old immunocompetent patient. HEV genomic RNA was detected in serum and cerebrospinal fluid samples (CSF), and molecular phylogenetic analysis of HEV was performed. The interest of this case lies in its detailed description notably the molecular analysis of HEV RNA isolated from serum and CSF. HEV infection should be considered in diagnostic investigations of neurologic manifestations associated with liver function perturbations.

KEYWORDS:

Hepatitis E; Neuralgic amyotrophy; Neurological disorders; Parsonage-Turner syndrome

PMID:
28439773
DOI:
10.1007/s13365-017-0525-0
[Indexed for MEDLINE]

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