Format

Send to

Choose Destination
Int J Clin Oncol. 2017 Oct;22(5):857-864. doi: 10.1007/s10147-017-1126-x. Epub 2017 Apr 24.

Post-recurrence chemotherapy for mesothelioma patients undergoing extrapleural pneumonectomy.

Author information

1
Department of Thoracic Surgery, Hyogo College of Medicine, 1-1 Mukogawacho, Nishinomiya, Hyogo, 663-8501, Japan. ttakuwa@hyo-med.ac.jp.
2
Department of Thoracic Surgery, Hyogo College of Medicine, 1-1 Mukogawacho, Nishinomiya, Hyogo, 663-8501, Japan.
3
Department of Respiratory Medicine, Hyogo College of Medicine, 1-1 Mukogawacho, Nishinomiya, Hyogo, Japan.

Abstract

BACKGROUND:

Additional chemotherapy is often not feasible in patients with recurrent malignant pleural mesothelioma (MPM) undergoing extrapleural pneumonectomy (EPP), due to deteriorated cardiopulmonary reserve. We thus examined the feasibility and efficacy of additional chemotherapy in patients with recurrent MPM after EPP.

METHODS:

A retrospective review was conducted of 59 consecutive patients who underwent bi-/tri-modal treatment with induction chemotherapy, EPP, and radiation therapy from July 2004 to August 2013 at Hyogo College of Medicine (Nishinomiya, Japan).

RESULTS:

Of 59 patients, 39 (male/female = 31/8, right/left = 15/24, pathological stage I/II/III/IV = 1/7/23/3, bi-/tri-modality = 27/12) relapsed at a median age of 62 (range 37-71) years. The median time to recurrence after EPP was 11.6 months. Of the 39 relapsed patients, 12 received best supportive care alone, six started but discontinued chemotherapy, and the remaining 21 (53%) completed more than three cycles of intravenous chemotherapy. The median survival time after EPP was significantly longer in 21 patients who received additional chemotherapy than in 18 patients who did not (39.2 vs. 12.2 months, P = 0.009).

CONCLUSIONS:

Additional systemic chemotherapy was successfully administered in more than 50% of relapsed patients after bi-/tri-modal treatment, which included EPP, and resulted in a longer survival in comparison with best supportive care alone.

KEYWORDS:

Best supportive care; Extrapleural pneumonectomy; Malignant pleural mesothelioma; Post-recurrence chemotherapy; Radiation therapy

PMID:
28439676
DOI:
10.1007/s10147-017-1126-x
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center