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Chem Commun (Camb). 2017 May 4;53(37):5182-5185. doi: 10.1039/c6cc08797c.

Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane.

Author information

1
Department of Chemistry, Imperial College London, London, UKSW7 2AZ. e.tate@imperial.ac.uk.
2
Medicine Design, Pfizer, 610 Main Street, Cambridge, MA 02139, USA.

Abstract

Sulforaphane is a small molecule isothiocyanate which exhibits anticancer potential, yet its biological targets remain poorly understood. Here we employ a competition-based chemical proteomics strategy to profile sulforaphane's targets and identify over 500 targets along with their relative affinities. These targets provide a new set of mediators for sulforaphane's bioactivity, and aid understanding of its complex mode of action.

PMID:
28439590
PMCID:
PMC6034444
DOI:
10.1039/c6cc08797c
[Indexed for MEDLINE]
Free PMC Article

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