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Ann Neurol. 2017 May;81(5):754-758. doi: 10.1002/ana.24935. Epub 2017 May 9.

Multiple sclerosis broke my heart.

Author information

1
Rhône-Alpes Multiple Sclerosis Network, Pierre Wertheimer Neurological Hospital, Hospices Civils de Lyon, Lyon/Bron.
2
Neurology Center, Clinique de la Sauvegarde, Lyon.
3
Department of Neurology C, Pierre Wertheimer Neurological Hospital, Hospices Civils de Lyon, Lyon/Bron.
4
Neurosciences pole, Neurology Unit B4, Pierre-Paul Riquet Hospital, Purpan University Hospital, Toulouse.
5
Department of Neurology, Strasbourg University Hospitals, Strasbourg.
6
Center for Clinical Investigation, INSERM U1434, Strasbourg.
7
Neurology, Multiple Sclerosis, Myelin Disorders and Neuroinflammation, Pierre Wertheimer Neurological Hospital, Hospices Civils de Lyon, Lyon/Bron.
8
Lyon Neurosciences Research Center, INSERM 1028 and CNRS UMR5292, Lyon.
9
Claude Bernard University Lyon 1, University of Lyon, Lyon.
10
Cardiovascular Functional Exploration Department, Louis Pradel Hospital, INSERM CIC1407 and U1060-CarMeN, Claude Bernard University Lyon 1, Hospices Civils de Lyon, Lyon.
11
Cardiology Intensive Care Unit, Federation of Cardiology, Rangeuil University Hospital, Toulouse.
12
Department of Internal Medicine, Edouard Herriot Hospital, Lyon, France.

Abstract

We report 5 cases of acute heart failure (AHF) related to multiple sclerosis (MS) relapses. AHF was inaugural in 3 patients, always preceded or accompanied by signs of brainstem dysfunction; it was severe, requiring intensive care management. Echocardiography showed left ventricular hypokinesis. No other cause of AHF has been found. All patients showed a new medullary lesion on brain magnetic resonance imaging. All had rapid and complete recovery of ventricular function after intravenous corticosteroids. We concluded that the cases represent a takotsubo phenomenon. Physicians should be aware of rare cases of takotsubo cardiomyopathy in MS relapses. Ann Neurol 2017;81:754-758.

PMID:
28437859
DOI:
10.1002/ana.24935
[Indexed for MEDLINE]

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