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Nature. 1988 Sep 29;335(6189):445-8.

Lymphocyte activation by HIV-1 envelope glycoprotein.

Author information

1
Pulmonary Center, Boston University School of Medicine, Boston, Massachusetts 02118.

Abstract

Cell activation by phytohaemagglutinin, phorbol ester and by the supernatant of phytohaemagglutinin-stimulated peripheral blood mononuclear cells induces the expression and cytopathic effects of latent human immunodeficiency virus type-1 (HIV-1) in vitro. The lymphocyte surface protein CD4 has been identified as a receptor for HIV-1 and binds the viral envelope glycoprotein (gp120). In the light of evidence indicating that one natural function of CD4 is as a growth factor receptor, we examined the ability of native gp120 to activate resting CD4-bearing lymphocytes. Our results indicate that gp120 has innate biological activity as a result of a specific interaction with CD4, inducing increases in intracellular levels of inositol trisphosphate and of calcium, and in interleukin-2 receptor expression and cell motility.

PMID:
2843775
DOI:
10.1038/335445a0
[Indexed for MEDLINE]

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