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Psychiatry Res. 2017 Aug;254:8-11. doi: 10.1016/j.psychres.2017.04.025. Epub 2017 Apr 14.

Genome-wide association study of treatment response to venlafaxine XR in generalized anxiety disorder.

Author information

1
Division of Intramural Clinical and Biological Research, National Institute of Alcohol Abuse and Alcoholism, Bethesda, MD, United States.
2
Section on Clinical Genomics and Experimental Therapeutics, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, United States.
3
Department of Psychiatry, Mood and Anxiety Disorders Treatment and Research Program, University of Pennsylvania, Philadelphia, PA, United States.
4
Section on Clinical Genomics and Experimental Therapeutics, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, United States; Department of Psychiatry, Mood and Anxiety Disorders Treatment and Research Program, University of Pennsylvania, Philadelphia, PA, United States. Electronic address: falk.lohoff@nih.gov.

Abstract

We conducted the first genome-wide association study (GWAS) in Generalized Anxiety Disorder (GAD) to identify potential predictors of venlafaxine XR treatment outcome. Ninety-eight European American patients participated in a venlafaxine XR clinical trial for GAD, with Hamilton Anxiety Scale (HAM-A) response/remission at 24 weeks as the primary outcome measure. All participants were genotyped with the Illumina PsychChip, and 266,820 common single nucleotide polymorphisms (SNPs) were analyzed. Although no SNPs reached genome-wide significance, 8 SNPs were marginally associated with treatment response/remission and HAM-A reduction at week 12 and 24 (p<0.00001). Several identified genes may indicate markers crossing neuropsychiatric diagnostic categories.

TRIAL REGISTRATION:

ClinicalTrials.gov NCT00183274.

KEYWORDS:

Generalized anxiety disorder; Pharmacogenetics; Venlafaxine XR

PMID:
28437668
PMCID:
PMC5798606
DOI:
10.1016/j.psychres.2017.04.025
[Indexed for MEDLINE]
Free PMC Article

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