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J Altern Complement Med. 2017 Aug;23(8):599-606. doi: 10.1089/acm.2016.0302. Epub 2017 Apr 24.

Serenoa repens for Lower Urinary Tract Symptoms/Benign Prostatic Hyperplasia: Current Evidence and Its Clinical Implications in Naturopathic Medicine.

Author information

1
1 Centre of Complementary and Alternative Medicine , Singapore, Singapore .
2
2 School of Biomedical Sciences, Charles Sturt University , Bathurst, Australia .

Abstract

OBJECTIVES:

Benign prostatic hyperplasia (BPH) commonly affects men above 40 years old. The progression of BPH is often accompanied with lower urinary tract symptoms (LUTS) that can significantly affect the quality of life of the patients. Serenoa repens (saw palmetto) is a popular herbal remedy indicated for LUTS/BPH. We reviewed the current research on the efficacy of S. repens on LUTS/BPH as a monotherapy as well as combination therapies.

DESIGN:

Non-systematic searches were performed in PubMed for human studies and systematic reviews on the topic.

RESULTS:

The latest evidence, based largely on the Cochrane review, suggests that S. repens is not superior to placebo in treating LUTS/BPH as a monotherapy, even at double and triple doses. Initial clinical trials on treatment of LUTS/BPH using S. repens with lycopene and selenium, as well as S. repens with Urtica Dioica, have shown positive results. S. repens is safe in its application. However, there is a high level of heterogeneity in the quality of S. repens products. We suggest that strong placebo effect, potentially influenced by positive patients' expectation on S. repens, shapes both the clinical practice outcomes and the findings of clinical trials. Hitherto, the totality of evidence continues to suggest that S. repens is a prudent therapeutic option as part of the naturopathic treatment for LUTS/BPH.

CONCLUSIONS:

The totality of evidence includes favorable patients' response from clinical experience, impact of placebo effect, early positive studies, subjective nature of symptom reporting, pharmacological properties of S. repens, and potential synergistic effects when combined with other therapies.

KEYWORDS:

Serenoa repens; benign prostatic hyperplasia; combination therapy; lower urinary tract symptoms; monotherapy; phytotherapy

PMID:
28436684
DOI:
10.1089/acm.2016.0302
[Indexed for MEDLINE]

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