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Nat Rev Cardiol. 2017 Aug;14(8):484-491. doi: 10.1038/nrcardio.2017.57. Epub 2017 Apr 24.

Redefining the identity of cardiac fibroblasts.

Author information

1
Department of Medicine, Center for Cardiovascular Research, University of Hawaii, Honolulu, Hawaii 96813, USA.
2
Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati, 3333 Burnet Avenue, Cincinnati, Ohio 45229-3026, USA.
3
The Howard Hughes Medical Institute, 240 Albert Sabin Way, Cincinnati, Ohio 45229-3039, USA.

Abstract

Cardiac fibroblasts deposit and maintain extracellular matrix during organogenesis and under physiological conditions. In the adult heart, activated cardiac fibroblasts also participate in the healing response after acute myocardial infarction and during chronic disease states characterized by augmented interstitial fibrosis and ventricular remodelling. However, delineation of the characteristics, plasticity, and origins of cardiac fibroblasts is an area of ongoing investigation and controversy. A set of genetic mouse models has been developed that specifically addresses the nature of these cells, in terms of both their origins and their response during cardiac disease and ventricular remodelling. As our understanding of cardiac fibroblasts becomes more defined and refined, so does the potential to develop new therapeutic strategies to control fibrosis and adverse ventricular remodelling.

PMID:
28436487
PMCID:
PMC6329009
DOI:
10.1038/nrcardio.2017.57
[Indexed for MEDLINE]
Free PMC Article

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