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J Diabetes. 2018 Jun;10(6):487-495. doi: 10.1111/1753-0407.12563. Epub 2017 Sep 29.

Plasma concentrations of lipids during pregnancy and the risk of gestational diabetes mellitus: A longitudinal study.

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Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland, USA.
Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, Iowa, USA.
Division of Research, Kaiser Permanente Northern California, Oakland, California, USA.
Glotech Inc., Rockville, Maryland, USA.
Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA.



Abnormal lipid profiles have been associated with gestational diabetes mellitus (GDM), but studies with longitudinal measures of lipids throughout pregnancy are sparse. The aim of the present study was to characterize longitudinal changes in lipid profiles throughout pregnancy and prospectively examine the associations of plasma lipid concentrations with risk of GDM.


This study was a nested case-control study including 107 GDM cases and 214 matched non-GDM controls from participants in the National Institute of Child Health and Human Development (NICHD) Fetal Growth Studies - Singleton cohort. Blood samples were collected longitudinally at Gestational Weeks (GW) 10-14, 15-26 (fasting sample), 23-31, and 33-39. Plasma concentrations of triglycerides, total cholesterol, and high-density lipoprotein cholesterol (HDL-C) were measured by enzymatic assays. Low-density lipoprotein cholesterol (LDL-C) was calculated using Friedewald's formula.


Plasma triglycerides, total cholesterol, and LDL-C increased as pregnancy progressed. At GW 10-14, the adjusted odds ratios (aORs) of GDM comparing the highest versus lowest quartile were 3.15 (95% confidence interval [CI] 1.38-7.15; P trend  = 0.002) for triglycerides and 0.44 (95% CI 0.18-1.09; P trend  = 0.045) for HDL-C. At GW 15-26, the aORs were 6.57 (95% CI 2.25-19.17; P trend  = 0.001) for triglycerides and 0.23 (95% CI 0.08-0.63; P trend  = 0.005) for HDL-C. No significant associations were observed for total cholesterol and LDL-C concentrations with risk of GDM.


Higher plasma triglyceride and lower HDL-C concentrations in early and mid-pregnancy were significantly associated with a greater risk of GDM. Total cholesterol and LDL-C concentrations during pregnancy were not significantly associated with GDM risk.


cholesterol; gestational diabetes; lipids; pregnancy; triglycerides; 三酰甘油; 妊娠; 妊娠糖尿病; 胆固醇; 血脂

[Available on 2019-06-01]
[Indexed for MEDLINE]

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