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Neurosci Res. 2017 May;118:66-73. doi: 10.1016/j.neures.2017.04.008. Epub 2017 Apr 20.

The control of sleep and wakefulness by mesolimbic dopamine systems.

Author information

1
International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, 305-8575, Japan. Electronic address: oishi.yo.fu@u.tsukuba.ac.jp.
2
International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, 305-8575, Japan.

Abstract

The mesolimbic dopamine pathway between the ventral tegmental area (VTA) and the nucleus accumbens (NAc) plays a central role in motivational behaviors. Recent findings indicate that the VTA and NAc are also involved in sleep/wake regulation - the topic of this review. First, we present an overview of the growing evidence from rodent studies revealing a wake-regulatory role of VTA dopamine neurons. We also discuss brain areas and their neurotransmitters or neuromodulators that may regulate the activity of wake-promoting VTA dopamine neurons. This is followed by a summary of current knowledge of the role of the NAc in regulating slow-wave sleep and a discussion of where and how this control of sleep physiology might be regulated by upstream neurotransmitters and neuromodulators, including dopamine and the classic somnogen adenosine.

KEYWORDS:

Chemogenetics; EEG; NAc; Neurotransmitters; VTA

PMID:
28434991
DOI:
10.1016/j.neures.2017.04.008
[Indexed for MEDLINE]

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