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J Am Acad Dermatol. 2017 Jun;76(6):1061-1067.e2. doi: 10.1016/j.jaad.2017.02.040. Epub 2017 Apr 20.

Alcohol intake and risk of rosacea in US women.

Author information

1
Department of Epidemiology, School of Public Health, Shandong University, Jinan, Shandong Province, China.
2
Department of Dermatology, Warren Alpert Medical School, Brown University, Providence, Rhode Island; Department of Epidemiology, School of Public Health, Brown University, Providence, Rhode Island; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
3
Department of Dermatology, Warren Alpert Medical School, Brown University, Providence, Rhode Island.
4
Department of Dermatology, Warren Alpert Medical School, Brown University, Providence, Rhode Island; Department of Epidemiology, School of Public Health, Brown University, Providence, Rhode Island. Electronic address: wen-qing_li@brown.edu.

Abstract

BACKGROUND:

The epidemiologic association between alcohol and rosacea is unclear and inconsistent based on the previous cross-sectional or case-control studies.

OBJECTIVE:

We conducted a cohort study to determine the association between alcohol intake and the risk of rosacea in women.

METHODS:

A total of 82,737 women were included from the Nurses' Health Study II (1991-2005). Information on alcohol intake was collected every 4 years during follow-up. Information on history of clinician-diagnosed rosacea and year of diagnosis was collected in 2005.

RESULTS:

Over 14 years of follow-up, we identified 4945 cases of rosacea. Compared with never drinkers, increased alcohol intake was associated with a significantly increased risk of rosacea (Ptrend <.0001). The multivariate-adjusted hazard ratios (HRs) and confidence intervals (CIs) were 1.12 (95% CI 1.05-1.20) for alcohol intake of 1-4 g/day and 1.53 (1.26-1.84) for ≥30 g/day. The associations remained consistent across categories of smoking status. Further examination of types of alcoholic beverage consumed revealed that white wine (Ptrend <.0001) and liquor intake (Ptrend = .0006) were significantly associated with a higher risk of rosacea.

LIMITATIONS:

This was an epidemiologic study without examination into etiologic mechanisms.

CONCLUSIONS:

Alcohol intake was significantly associated with an increased risk of rosacea in women.

KEYWORDS:

alcohol intake; cohort studies; dose-response relationship; epidemiology; rosacea; smoking

Comment in

PMID:
28434611
PMCID:
PMC5438297
DOI:
10.1016/j.jaad.2017.02.040
[Indexed for MEDLINE]
Free PMC Article

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